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Gianluca Mech specializes in the study of ketosis and boasts the highest number of international scientific publications in this field. The ketosis of Gianluca Mech, contrary to the commonly known ketosis, is a“phyto-ketosis”, namely ketosis “mitigated” by the presence of carefully selected medicinal herbs.

Ketogenic diet, weight loss and body composition

Cenci L, Fongaro S, Lukashina N, Marchetti B. (2019) Eat Weight Disord 2018 DOI 10.1007/s40519-018-0576-0
Health organizations report an increasing worldwide prevalence of overweight and obesity which is a great source of concern considering the fact that obesity and in particular abdominal obesity is one of the principle risk factors for cardiovascular disease and is strongly linked to dyslipidaemia, hypertension, diabetes and metabolic syndrome ...

Ketogenic diet, weight loss and body composition | NO. 27 (2019)

Effects of the Ketogenic diet in overweight divers breathing Enriched Air Nitro

Bosco G et al - Scientific Reports | (2018) 8: 2655 | DOI: 10.1038 / s41598-018-20933-w.
Central Nervous System Oxygen Toxicity (CNS-OT) is one of the most harmful effects of Enriched Air Nitrox (EAN) diving, in which a mixture of air enriched with nitrogen (EAN) is used.
The literature shows that the ketogenic diet (KD) has protective effects such as enhanced antioxidant activity, the prevention of mitochondrial damage and anti-inflammatory mechanisms... Effects of the Ketogenic diet in overweight divers breathing Enriched Air Nitrox | NO. 26 (2018)

Role of the ketogenic diet in the reduction of anaesthetic and surgical risk

Cenci L et al - Minerva Gastroenterol Dietol. 2018 Mar; 64 (1): 84-93.
Obesity has become one of the most serious health problems in the western world and abdominal obesity, in particular, is one of the main cardiovascular risk factors that, together with dyslipidaemia, hypertension and diabetes, are the major contributing factors to the metabolic syndrome. 

Role of the ketogenic diet in the reduction of anaesthetic and surgical risk | NO. 25 (2018)

The role of the Ketogenic diet in patients with heart disease

Cenci L et al - Proceedings of the National Congress of the "Società Italiana Nutrizione Parenterale ed Enterale" Milan, 23-25 November 2017
This research demonstrates how the ketogenic diet is safe from a medical point of view and suitable for those with an increasingly frequent and problematic pathological condition (with a prevalence of 2% of the general population, 80,000 new cases a year).

The Effects of Different High-Protein Low-Carbohydrate Proprietary Foods on Blood Sugar in Healthy Subjects

Alessandra Lodi and al - J Med Food 19 (11) 2016, 1-11
Ultra-processed with a high level of good quality protein and fibre could improve both the diet of young people and the diet of those with type 2 diabetes (T2DM). Young people are often in the habit of eating high-calorie and very sugary snacks which lack fibre and protein and are full of saturated fatty acids; they would improve their diet by eating this type of food and have a lower risk of developing type 2 diabetes... The Effects of Different High-Protein Low-Carbohydrate Proprietary Foods on Blood Sugar in Healthy Subjects | NO. 23 (2016)

Effects of Twenty Days of the Ketogenic Diet on Metabolic and Respiratory Parameters in Healthy Subjects

Rubini A et al - Lung 2015 Sept 26 DOI 10.1007/s00408-015-9806-7
A study to investigate the effects of the ketogenic diet (KD) on weight loss, metabolic diseases and respiratory parameters in healthy subjects. NO. 22 (2015) | Effects of Twenty Days of the Ketogenic Diet on Metabolic and Respiratory Parameters in Healthy Subjects

The effects of the introduction of polyunsaturated fatty acids on certain cardiovascular risk factors in a ketogenic diet

Paoli A et al - Marine Drugs. 2015 Feb 13; 13 (2): 996-1009
The ketogenic diet (KD) has become a widely used nutritional approach for weight loss. Some of the positive effects of a KD on cardiovascular risk factors are similar to those observed after the introduction of polyunsaturated fatty acids. We hypothesised that a ketogenic Mediterranean diet... The effects of the introduction of polyunsaturated fatty acids on certain cardiovascular risk factors in a ketogenic diet | NO. 21 (2015)

Ketogenic Diet for Obesity: Friend or Foe?

Paoli A. et al - Int J Environ Res Public Health. 2014 Feb 19; 11 (2): 2092-107
Obesity is reaching epidemic proportions and is a strong risk factor for a number of cardiovascular and metabolic disorders such as hypertension, type 2 diabetes, dyslipidaemia, atherosclerosis, and also certain types of cancers. Despite the constant recommendations of health care organizations regarding the importance of weight control, this goal often fails. Genetic predisposition in combination with inactive lifestyles... Ketogenic Diet for Obesity: Friend or Foe? | NO. 20 (2014)

Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases

Paoli A et al - Biomed Res Int. 2014; 2014: 474296
An increasing amount of data demonstrates the utility of ketogenic diets in a variety of metabolic diseases such as obesity, metabolic syndrome and diabetes. In regard to neurological disorders, ketogenic diet is recognized as an effective treatment for pharmaco-resistant epilepsy but emerging data suggests that ketogenic diets could be also useful in amyotrophic lateral sclerosis... Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases | NO. 19 (2014)

Successful long-term weight loss with a combination biphasic ketogenic Mediterranean diet and Mediterranean diet maintenance protocol.

Paoli A et al- Nutrients 2013, 5.5205-5217_; doi: 10.3390/nu5125205
Weight loss protocols can only be considered successful if they deliver consistent results over the long term - a goal which is often elusive, so much so that the term "yo-yo" is used to describe the perennial weight loss/weight regain battle common in obesity... Successful long-term weight loss with a combination biphasic ketogenic Mediterranean diet and Mediterranean diet maintenance protocol. | NO. 18 (2013)

Ketogenic Diet Does Not Affect Strength Performance in Elite Artistic Gymnasts

Paoli A et al - Journal of the International Society of Sports Nutrition 2012, 9:34
Despite the increasing use of very low carbohydrate ketogenic diets (VLCKD) in weight control and the management of metabolic syndrome, there is a paucity of research about effects of VLCKD on sport performance. ...the aim of our study was to investigate the influence of VLCKD on explosive strength performance.... Ketogenic Diet Does Not Affect Strength Performance in Elite Artistic Gymnasts | NO. 17 (2012)

Medium-term effects of a ketogenic diet and a Mediterranean diet on resting energy expenditure and respiratory ratio

Paoli A et al - BMC Proceedings 2012, 6 (Suppl 3): P37
Very low carbohydrate ketogenic type diets (VLCKD) have been shown to be more effective for body weight reduction and fat loss compared to balanced or low-calorie Mediterranean diets... Medium-term effects of a ketogenic diet and a Mediterranean diet on resting energy expenditure and respiratory ratio | NO. 16 (2012)

Phytoextracts in the ketogenic diet: what is the scientific rationale?

Faedo A et al - Medicinal Plants, Special Issue June 2012 - ISSN 1825-5086
A review of the current literature in order to verify if there is a rationale for the use of certain phytoextracts in the context of a commercial protocol for weight reduction, known as the Tisanoreica Method (TM). From the technical point of view, two different diet regimes are to be investigated: a ketogenic diet followed by a low-calorie diet... Phytoextracts in the ketogenic diet: what is the scientific rationale? | NO. 15 (2012)

A modified ketogenic diet with phytoextracts in the management of the patient with hyperuricemia and alterations in hepatic function

Cenci L et al - Medicinal Plants, Special Issue June 2012 - ISSN 1825-5086
The subject was a 58 year old male, during a weight reduction consultancy session (BMI 31.5). Routine blood tests were carried out, as referred to in the standard, with an agreement to send a copy of the results within a few days. The patient is a non-smoker, with regular bowel movements, undergoing treatment for hypertension with ACE inhibitors, calcium antagonists and diuretics. Reports suffering from gastro-oesophageal reflux not being treated with drugs...

Cases on the efficacy of a ketogenic diet supplemented with phyto-extracts

Faedo A et al - Medicinal Plants, Special Issue June 2012 - ISSN 1825-5086
The purpose of this study is to verify the effectiveness of a commercial protocol for weight reduction (the Tisanoreica Method) in order to have a legitimate expectation of weight loss. Study subjects and methodology: the case studies were evaluated at the Rossetto di Malcontenta Pharmacy in Mira (VE) and involved 189 persons divided as follows: 52 followed the Basic Protocol, 20 the Intermediate Protocol and 117 followed the Impact Protocol... Cases on the efficacy of a ketogenic diet supplemented with phyto-extracts | NO. 13 (2012)

Food Supplements and Eating Disorders

Cenci L et al - Proceedings of the XXIII Congress of the National Dietitians Association, Verona 19-21 / 04/2012
Verification of the usefulness of protein-based hypocaloric supplements in the management of eating disorders. Study subjects and methods: 10 women with eating disorders (age between 20-40) were identified, and a normal caloric diet was prescribed with sweet protein supplements with a tonic action... Food Supplements and Eating Disorders | NO. 12 (2012)

The effect of a Mediterranean ketogenic diet supplemented with phytoextracts and low-carbohydrate/high protein content: effects on weight, cardiovascular risk factors, body composition and compliance, on a group of employees

Paoli A et al - Nutrition Journal 2011, 10: 112
There has been a growing interest in recent years in low-carbohydrate or ketogenic diets that, even though they are much discussed and often opposed, have undoubtedly been shown to be effective, at least in the short to medium-term, as a treatment for obesity, dyslipidaemia and certain cardiovascular risk factors. For this reason, the ketogenic diet is an interesting option, but unfortunately suffers from low compliance...
The effect of a Mediterranean ketogenic diet supplemented with phytoextracts and low-carbohydrate/high protein content: effects on weight, cardiovascular risk factors, body composition and compliance, on a group of employees | NO. 11 (2012)

Preliminary evaluation of the effectiveness of a phytoextract on respiratory function

Babbolin G et al - Proceedings of the II Congress of the Italian Society of Gender Health and Medicine, Padua 21-23 / 10/2010
Evaluating the effectiveness of a phyto-therapeutic treatment in improving respiratory function. Methods - The study was performed on 30 subjects randomly divided into 2 groups of 15 subjects each (treated and untreated). Subsequently, a personal (gender, age), anthropometric (weight, height, BMI) and spirometric (FVC, FEV1) evaluation was carried out... Preliminary evaluation of the effectiveness of a phytoextract on respiratory function | NO. 10 (2010)

A comparison between the effects of a Mediterranean diet, the Zone diet and the Tisanoreica diet on hepatic and renal function and lipid structure

Paoli A et al - Agro Food Ind Hi-Tech 2010, 21:24-29
The purpose of this study was to test the efficacy of the three types of diets on certain anthropometric and metabolic variables such as weight loss, body composition, resting energy expenditure (REE) and respiratory quotient (RQ). We tested 44 subjects randomly assigned to one of the three diet groups: Mediterranean (MED), Zone (ZON) and Tisanoreica®, i.e. the ketogenic diet with phytoextracts (TIS) ... A comparison between the effects of a Mediterranean diet, the Zone diet and the Tisanoreica diet on hepatic and renal function and lipid structure | NO. 9 (2010)

The Ketogenic diet combined with of phyto-extracts for short-term reduction in weight in the overweight subject

Cenci L et al - Proceedings of the XXII Congress of the National Dietitians Association, Milan 20-22/05/2010
The aim of the study is to verify the efficacy of a ketogenic diet supplemented with phytoextracts to be used for weight reduction. VLCD (Very Low Carbohydrate Diet) induces a metabolic state (ketosis) that makes the transformation of nutrients into energy less efficient, contradicting the concept "a calorie is a calorie"... The Ketogenic diet combined with of phyto-extracts for short-term reduction in weight in the overweight subject | NO. 8 (2010)

A Ketogenic diet with the addition of plant extracts for the treatment of type 2 diabetes

Cenci L et al - Proceedings of the XXII Congress of the National Dietitians Association, Milan 20-22/05/2010
Before the advent of insulin injections for the treatment of diabetes mellitus, the therapy consisted of a ketogenic diet. There are studies in the literature that confirm the positive effects of the ketogenic diet on the glycemic profile. The aim of the study is to verify the efficacy of a ketogenic diet in improving metabolic compensation and in reducing the use of any drug therapy in progress... A Ketogenic diet with the addition of plant extracts for the treatment of type 2 diabetes | NO. 7 (2010)

Antioxidants, diet and lifestyle: resources of choice against oxidative stress

Migliorati A et al - Medicinal Plants, Special Issue May 2010 - ISSN 1825-5086
Over the last thirty years, more than 6,000 studies in the literature have affirmed that oxidative stress is a determining cause of a large number of degenerative and neoplastic diseases and is responsible for ageing... NO. 6 (2010) | Antioxidants, diet and lifestyle: resources of choice against oxidative stress

A low-calorie diet with phyto-extracts for the treatment of overweight people

Cenci L et al - Medicinal Plants, Special Issue May 2010 - ISSN 1825-5086
The aim of the study is to verify the utility of adding phytoextracts, with a tonic and adaptogen effect, to a slightly hypocaloric diet. Methods: inclusion criteria: age between 25 and 75, BMI between 25 and 40, a desire to lose weight and no pathology present... A low-calorie diet with phyto-extracts for the treatment of overweight people | NO. 5 (2010)

Phyto-extracts for the treatment of constipation

Cenci L et al - The Internet Journal of Nutrition and Wellness - 2009, issue 8 number 2
Given that constipation is a frequent problem in a proportion of the adult population and in almost all the geriatric population, after approval by the Ethics Committee, we have tested an herbal food supplement, indicated for the regularisation of the... Phyto-extracts for the treatment of constipation | NO. 4 (2009)

Phytoextracts for management of cholesterolemia

Cenci L et al- Proceedings of the XXXI Congress of the Italian Society of Internal Medicine, Bologna 17/10/2009
The Seven Countries Study, conducted on 12,467 men aged between 40 and 59 years of age, confirmed that an increase in cholesterolemia of 20 mg/dL corresponded to an increase of about 12% in the risk of coronary mortality. The lowest incidence of mortality is observed in countries where the population has cholesterolemia values ​​between 125 and 150 mg/dL... Phytoextracts for management of cholesterolemia | NO. 3 (2009)

An evaluation of the effects of a food supplement on self-esteem, physical efficiency and infection

Paoli A et Al; Acts of the XXXI congress of the Italian Society of Internal Medicine, Bologna 17/10/2009
We tested an herbal food supplement advertised for its immuno-stimulating properties (dosage 50 ml diluted in 1 litre of water to be taken during the day). According to the WHO, immuno-modulators should degrade rapidly, have no side effects and have a moderate immuno-stimulating effect... An evaluation of the effects of a food supplement on self-esteem, physical efficiency and infection | NO. 2 (2009)

Evaluation of the effectiveness of the Tisanoreica method in the Basic, Intermediate and Impact Protocols

Cenci L et al - Proceedings of the XXXI Congress of the Italian Society of Internal Medicine, Bologna 17/10/2009
The purpose of this study is to test the effectiveness of the various protocols (Basic, Intermediate and Impact), as presented by the Tisanoreica method, on a group of overweight or obese people without the concomitant presence of other pathological forms... Evaluation of the effectiveness of the Tisanoreica method in the Basic, Intermediate and Impact Protocols | NO. 1 (2009)